General Framework
Structure
Main National and International Collaborations and Reference Groups
Areas of Research
Main ongoing Research Activities and Projects
Methodologies and Facilities
Selected References
Cardio.Care
Internet links in cardiology
7. REFERENCES


Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI).
Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986; i: 397-402.

Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI).
Long-term effects of intravenous thrombolysis in acute myocardial infarction: final report of the GISSI study. Lancet 1987; ii: 871-874.

Gruppo di Studio sulla Pressione Arteriosa nell'Anziano.
Feasibility of a large prospective study in general practice: an Italian experience. Br Med J 1987; 294: 157-160.

Volpi A, Maggioni AP, Franzosi MG, Pampallona S, Mauri F, Tognoni G.
In-hospital prognosis of patients with acute myocardial infarction complicated by primary ventricular fibrillation. N Engl J Med 1987; 317: 257-261.

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2).
GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12,490 patients with acute myocardial infarction. Lancet 1990; 336: 65-71.

Latini R, Maggioni AP, Cavalli A.
Therapeutic drug monitoring of antiarrhythmic drugs. Rationale and current status. Clin Pharmacokinet 1990; 18: 91-103.

Tognoni G, Franzosi MG, Garattini S, Maggioni AP, Lotto A, Mauri F, Rovelli F.
The case of GISSI in changing the attitudes and practice of Italian cardiologists. Stat Med 1990; 9: 17-27.

Zatta A, Prosdocimi M, Bertele' V, Bazzoni G, Del Maschio A.
Inhibition of platelet function by polymorphonuclear leukocytes. J Lab Clin Med 1990; 116: 651-660.

Zuanetti G, Hoyt RH,
Corr PB: beta-adrenergic-mediated influences on microscopic conduction in epicardial regions overlying infarcted myocardium. Circ Res 1990; 67: 284-302.

Maggioni AP, Franzosi MG, Farina ML, Santoro E, Celani MG, Ricci S, Tognoni G.
Cerebrovascular events after myocardial infarction: analysis of the GISSI trial. Br Med J 1991; 302: 1428-1431.

Tognoni G, Alli C, Avanzini F, Bettelli G, Colombo F, Corso R, Marchioli R, Zussino A.
Randomised clinical trials in general practice: lessons from a failure. Br Med J 1991; 303: 969-971.

Zuanetti G, Latini R, Neilson JMM, Schwartz PJ, Ewing DJ and the Antiarrhythmic Drug Evaluation Group (ADEG).
Heart rate variability in patients with ventricular arrhythmias: effect of antiarrhythmic drugs. J Am Coll Cardiol 1991; 17: 604-612.

Alli C, Avanzini F, Bettelli G, Bonati M, Colombo F, Corso R, Di Tullio M, Gentile MG, Sangalli L, Taioli E, Tognoni G and the participating doctors.
Feasibility of a long-term low-sodium diet in mild hypertension. J Hum Hypertens 1992; 6: 281-286.

Alli C, Avanzini F, Bettelli G, Colombo F, Corso R, Di Tullio M, Marchioli R, Mariotti G, Radice M, Taioli E, Terzian E, Tognoni G, Zussino A and the participating doctors of the "Gruppo di studio sulla pressione arteriosa nell'anziano".
Prevalence and variability of orthostatic hypotension in the elderly. Results of the "Italian study on blood pressure in the elderly (SPAA)". Eur Heart J 1992; 13: 178-182.

Antiarrhythmic Drug Evaluation Group.
A multicentre, randomized trial on the benefit/risk profile of amiodarone, flecainide and propafenone in patients with cardiac disease and complex ventricular arrhythmias. Eur Heart J 1992; 13: 1251-1258.

Bernasconi R, Caliari S, Latini R, Leopaldi D, Porzio S, Salimbeni A.
Pharmacokinetics of diltiazem and a new analogue, LR-A/113, in the conscious rat. Eur J Drug Metab Pharmacokinet 1992; 17: 269-274.

GISSI-2 and International Study Group.
Six-month survival in 20891 patients with acute myocardial infarction randomized between alteplase and streptokinase with or without heparin. Eur Heart J 1992; 13: 1692-1697.

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-3).
GISSI-3: Study protocol on the effects of lisinopril, of nitrates, and of their association in patients with acute myocardial infarction. Am J Cardiol 1992; 70: 62C-69C.

Maggioni AP, Franzosi MG, Santoro E, White H, Van de Werf F, Tognoni G, the GISSI-2 and the International Study Group.
The risk of stroke in patients with acute myocardial infarction after thrombolytic and antithrombotic treatment.

N Engl J Med 1992; 327: 1-6.

Roncaglioni MC, Santoro L, D'Avanzo B, Negri E, Nobili A, Ledda A, Pietropaolo F, Franzosi MG, LaVecchia C, Feruglio GA, Maseri A on behalf of GISSI-EFRIM Investigators.
Role of family history in patients with myocardial infarction. An Italian case-control study. Circulation 1992; 85: 2065-2072.

Alli C, Avanzini F, Caimi V, Colombo F, Parma E, Passerini G, Tognoni G.
General practitioners' approach to the detection and treatment of hypertension. An Italian survey. High Blood Press 1993; 2: 283-290.

Collaborative Group on Heparin Prophylaxis in Surgery (SEPEC), Pangrazzi J, Donati MB, Romero M, Scroccaro G, Colombo F, Terzian E Tognoni G.
Is there still an avoidable fraction of post-operative thromboembolic complications with heparin prohylaxis? The results of a case-control surveillance. J Clin Epidemiol 1993; 46: 371-377.

Maggioni AP, Maseri A, Fresco C, Franzosi MG, Mauri F, Santoro E, Tognoni G on behalf of the Investigators of the GISSI-2.
Age-related increase in mortality among patients with first myocardial infarction treated with thrombolysis. N Engl J Med 1993; 329: 1442-1448.

Maggioni AP, Zuanetti G, Franzosi MG, Rovelli F, Santoro E, Staszewsky L, Tavazzi L, Tognoni G on behalf of GISSI-2 Investigators.
Prevalence and prognostic significance of ventricular arrhythmias after acute myocardial infarction in the fibrinolytic era. GISSI-2 results. Circulation 1993; 87: 312-322.

Pizzetti F, Peci P, Manni B, Bonaglia M, Ghio S, Latini R, Avanzini F.
Noninvasive evaluation of acute hemodynamic effects of sublingual and transdermal nitroglycerin in man. G Ital Cardiol 1993; 23: 327-334.

Santoro E, Franzosi MG, Nicolis E.
A computerized network system for the management of a large scale multicentre clinical trial: the GISSI-3 trial. Controlled Clin Trials 1993; 14: 430.
 
Simoons ML, Maggioni AP, Knatterud G, Leimberger DJ, de Jaegere P, van Domburg R, Boersam E, Franzosi MG, Califf R, Schröder R, Braunwald E.
Individual risk assessment for intracranial haemorrhage during thrombolytic therapy. Lancet 1993; 342: 1523-1528.

Volpi A, De Vita C, Franzosi MG, Geraci E, Maggioni AP, Mauri F, Negri E, Santoro E, Tavazzi L, Tognoni G, the ad hoc Working Groups of the GISSI-2 Data Base.
Determinants of 6-month mortality in survivors of myocardial infarction after thrombolysis. Results of the GISSI-2 data base. Circulation 1993; 88: 416-429.

Zuanetti G, Latini R, Maggioni AP, Santoro L, Franzosi MG on behalf of GISSI-2 Investigators.
Influence of diabetes on mortality in acute myocardial infarction: data from the GISSI-2 study. J Am Coll Cardiol 1993; 22: 1788-1794.

Avanzini F, Alli C, Bettelli G, Corso R, Colombo F, Mariotti G, Radice M, Torri V, Tognoni G.
Antihypertensive efficacy and tolerability of different drug regimens in isolated systolic hypertension in the elderly. Eur Heart J 1994; 14: 206-212.

Fibrinolytic Therapy Trialists' (FTT) Collaborative Group.
Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet 1994; 343: 311-322.

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI).
GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994; 343: 1115-1122.

Latini R, Bianchi M, Correale E, Dinarello CA, Fantuzzi G, Fresco C, Maggioni AP, Mengozzi M, Romano S, Shapiro L, Sironi M, Tognoni G, Turato R, Ghezzi P.
Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist. J Cardiovasc Pharmacol 1994; 23: 1-6.

Marino P, Nidasio G, Golia G, Franzosi MG, Maggioni AP, Santoro E, Santoro L, Zardini P, on behalf of the GISSI-2.
Frequency of predischarge ventricular arrhythmias in postmyocardial infarction patients depends on residual left ventricular pump performance and is independent of the occurrence of acute reperfusion. J Am Coll Cardiol 1994; 23: 290-295.

Mauri F, Maggioni AP, Franzosi MG, De Vita C, Santoro E, Santoro L, Giannuzzi P, Tognoni G for the GISSI-2 Investigators.
A simple electrocardiographic predictor of the outcome of patients with acute myocardial infarction treated with a thrombolytic agent. J Am Coll Cardiol 1994; 24: 600-607.

Avanzini F, Latini R, Maggioni AP, Colombo F, Santoro E, Franzosi MG, Tognoni G, on behalf of the GISSI Investigators.
Antiarrhythmic drug prescription in post-myocardial infarction patients in the last decade: experience of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (GISSI). Arch Intern Med 1995; 155: 1041-1045.

Collaborative Group of the Primary Prevention Project.
Epidemiological feasibility of cardiovascular primary prevention in general practice: a trial of vitamin E and aspirin. J Cardiovasc Risk 1995; 2: 137-142.

Gattinoni L, Brazzi L, Pelosi P, Latini R, Tognoni G, Pesenti A, Fumagalli R, for the SVO2 Collaborative Group.
A trial of goal-oriented hemodynamic therapy in critically ill patients. N Engl J Med 1995; 333: 1025-1032.

GISSI-Avoidable Delay Study Group.
Epidemiology of avoidable delay in the care of acute myocardial infarction patients in Italy: a GISSI generated study. Arch. Inter Med 1995; 155: 1481-1488.

Latini R, Maggioni AP, Flather M, Sleight P, Tognoni G, for the meeting participants.
ACE inhibitor use in patients with myocardial infarction. Circulation 1995; 92: 3132-3137.

Multicentre Acute Stroke Trial-Italy (MAST-I) Group.
Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Lancet 1995; 346: 1509-1514.

Porzio S, Masseroli M, Messori A, Forloni G, Olivetti G, Jeremic G, Riva E, Luvarà G, Latini R.
A simple, automatic method for morphometric analysis of the left ventricle in rats with myocardial infarction. J Pharmacol Toxicol Methods 1995; 33: 221-229.

Riva E, Kurosaki M, Porzio S, Latini R, Lagrasta C, Olivetti G.
Effects of an early treatment with lisinopril and isosorbide-5-mononitrate on haemodynamics and late ventricular remodelling in rats with 9-week myocardial infarction. Cardioscience 1995; 6: 139-146.

Tognoni G.
Dissent: an alternative interpretation of MAST-I. Lancet 1995; 346: 1515.

Villella A, Maggioni AP, Villella M, Giordano A, Turazza FM, Santoro E, Franzosi MG, on the behalf of GISSI-2 Investigators.
Prognostic significance of maximal exercise testing after myocardial infarction treated with thrombolytic agents: the GISSI-2 data-base. Lancet 1995; 346: 523-529.

Avanzini F, Tognoni G, Alli C, Colombo F, Herxheimer A, on behalf of the International Society of Drug Bulletins (ISDB).
How informed general practitioners manage mild hypertension. A survey of readers of drug bulletins in 7 countries. Eur J Clin Pharmacol 1996; 49: 445-450.

Fresco C, Avanzini F, Bosi S, Franzosi MG, Maggioni AP, Santoro L, Bellanti G, on behalf of GISSI-2 Investigators.
Prognostic value of a history of hypertension in 11,483 patients with acute myocardial infarction treated with thrombolysis. J Hypertension 1996; 14: 743-750.

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico.
Six-month effects of early treatment with lisinopril and transdermal glyceryl trinitrate singly and together withdrawn six weeks after acute myocardial infarction: The GISSI-3 trial. J Am Coll Cardiol 1996; 27: 337-344.

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (Writing Commitee: Nicolosi GL, Latini R, Marino P, Maggioni AP, Barlera S, Franzosi MG, Geraci E, Santoro L, Tavazzi L, Tognoni G, Vecchio C, Volpi A).
The prognostic value of predischarge quantitative two-dimensional echocardiographic measurements and the effects of early lisinopril treatment on left ventricular structure and function after acute myocardial infarction in the GISSI-3 Trial. Eur Heart J 1996; 17: 1646-1656.

Jeremic G, Masson S, Luvarà G, Porzio S, Lagrasta C, Riva E, Olivetti G, Latini R.
Effects of a new angiotensin-converting enzyme inhibitor (Idrapril) in rats with left-ventricular dysfuction after myocardial infarction. J Cardiovasc Pharmacol; 1996; 27: 347-354.

Labbrozzi D, Carinci F, Nicolucci A, Bettinardi O, Zotti AM, Tognoni G, a nome del Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI).
Psychological carachteristics of patients with myocardial infarction: the GISSI-2 results. G Ital Cardiol 1996; 26: 85-106.

Santoro E, Nicolis E, Franzosi MG. A practical use of the Internet in cardiology.
G Ital Cardiol 1996; 26: 775-792.

The i.c.a.i. Group (Gruppo di studio dell'ischemia cronica critica degli arti inferiori).
A pospective epidemiological survey of the natural history of chronic critical leg ischaemia. Eur J Vasc Endovasc Surg 1996; 11: 112-120.

The i.c.a.i. Group (Gruppo di studio dell'ischemia cronica critica degli arti inferiori).
Rationale and methodology of the i.c.a.i. study, a randomised clinical trial of alprostadil in the treatment of chronic critical leg ischemia. J Nephrol 1996; 9: 93-98.

Zuanetti G, Latini R, Avanzini F, Franzosi MG, Maggioni AP, Colombo F, Nicolis E, Mauri F, on behalf of GISSI Investigators.
Trends and determinants of calcium antagonists usage after acute myocardial infarction (the GISSI experience). Am J Cardiol 1996; 78: 153-157.

Zuanetti G, Neilson JMN, Latini R, Santoro E, Maggioni AP, Ewing DJ, on behalf of GISSI-2 Investigators.
Prognostic significance of heart rate variability in post-myocardial infarction patients in the fibrinolytic era: the GISSI-2 results. Circulation 1996; 94: 432-436.

Avanzini F, Zuanetti G, Latini R, Colombo F, Santoro E, Maggioni AP, Franzosi MG, Tognoni G, on behalf of the Gruppo Italiano di Studio sulla Sopravvivenza nell'Infarto Miocardico (GISSI) Investigators.
Use of beta-blocking agents in secondary prevention after myocardial infarction: a case for evidence-based medicine? GISSI experience, 1984-1993. Eur Heart J 1997; 18: 1447-1456.

Bevilacqua M, Vago T, Baldi G, Norbiato G, Masson S, Latini R.
Analytical agreement and clinical correlates of plasma brain natriuretic peptide measured by three immunoassays in patients with heart failure. Clin Chem 1997; 43: 2439-2440.

Carinci F, Nicolucci A, Ciampi A, Labbrozzi D, Bettinardi O, Zotti AM, Tognoni G, on behalf of the Gruppo Italiano per lo Studio della Sopravvivenza all'Infarto Miocardico.
Role of interactions between psychological and clinical factors in determining 6-month mortality among patients with acute myocardial infarction. Application of recursive partitioning techniques to the GISSI-2 Data-base. Eur Heart J 1997; 18: 835-845.

Collaborative Organization for RheothRx Evaluation (CORE).
Effects of RheothRx on mortality, morbidity, left ventricular function, and infarct size in patients with acute myocardial infarction. Circulation 1997; 96: 192-201.

GISSI-Nursing.
Evaluation of health-related of life by myocardial infarction patients. G Ital Cardiol 1997; 27: 865-876.

Tavazzi L, Volpi A, for the GISSI Investigators.
Remarks about postinfarction prognosis in light of the experience with the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) Trial. Circulation 1997; 95: 1341-1345.

Tognoni G, Fresco C, Maggioni AP, Turazza FM, on behalf of GISSI Investigators.
The GISSI story (1983-1996): a comprehensive view. J Interven Cardiol 1997; 10: 3-28.

Tsuyuki RT, Yusuf S, Rouleau JL, Maggioni AP, McKelvie RS, Wieck EM, Wang Y, Pogue J, Teo KK, White M, Avezum Jr A, Latini R, Held P, Lindgren E, Probstfield J, for the RESOLVD Pilot Study Investigators.
Combination neurohormonal blockade with ACE inhibitors, angiotensin II antagonists and beta-blockers in patients with congestive heart failure: Design of the Randomized Evaluation of Strategies for Left Ventricular Disfunction (RESOLVD) Pilot Study. Can J Cardiol 1997; 13: 1166-1174.

The i.c.a.i. Group (Gruppo di studio dell'ischemia cronica critica degli arti inferiori).
Long-term mortality and its predictors in patients with critical leg ischaemia. Eur J Vasc Endovasc Surg 1997; 14: 91-95.

Zuanetti G, Latini R, Maggioni AP, Franzosi MG, Santoro L, Tognoni G, for the GISSI-3 Investigators.
Effect of the ACE-inhibitor lisinopril on mortality in diabetic patients with acute myocardial infarction. Data from the GISSI-3 study. Circulation 1997; 96: 4239-4245.

ACE Inibitor Myocardial Infarction Collaborative Group.
Indications for ACE inhibitors in the early treatment of acute myocardial infarction. Systematic overview of individual data from 100000 patients in randomized trials. Circulation 1998; 97: 2202-2212.

Annoni G, Luvarà G, Arosio B, Gagliano N, Fiordaliso F, Santambrogio D, Jeremic G, Mircoli L, Latini R, Vergani C, Masson S.
Age-dependent expression of fibrosis-related genes and collagen deposition in the rat myocardium. Mech Ageing Dev 1998; 101: 57-72.

Franzosi MG, Maggioni AP, Santoro E, Tognoni G, Cavalieri E.
Cost-effectiveness analysis of early lisinopril use in patients with acute myocardial infarction. Results from GISSI-3 Trial. Pharmacoeconomics 1998; 13: 337-346.

GISSI-Nursing.
Context and background after an infarction. G Ital Cardiol 1998; 28: 281-287.

Latini R, Masson S, Jeremic G, Luvarà G, Fiordaliso F, Calvillo L, Bernasconi R, Torri M, Rondelli I, Razzetti R, Bongrani S.
Comparative efficacy of a DA2/alpha2 agonist and a beta-blocker in reducing adrenergic drive and cardiac fibrosis in a experimental model of left ventricular dysfunction after coronary artery occlusion. J Cardiovasc Pharmacol 1998; 31: 601-608.

Maggioni AP, Piantadosi F, Tognoni G, Santoro E, Franzosi MG, on behalf of the Investigators of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI-2).
Smoking is not a protective factor for patients with acute myocardial infarction: the viewpoint of GISSI-2 study. G Ital Cardiol 1998; 28: 970-978.

Masson S, Latini R, Bevilacqua M, Vago T, Sessa F, Torri M, Anesini A, Salio M, Pasotti E, Agnello D, Santoro L, Catania A, Ghezzi P, Moccetti T, Maggioni AP.
Within-patient variability of hormone and cytokine concentrations in heart failure. Pharmacol Research 1998; 37: 213-217.

Masson S, Arosio B, Luvarà G, Gagliano N, Fiordaliso F, Santambrogio D, Vergani C, Latini R, Annoni G.
Remodelling of cardiac extracellular matrix during beta-adrenergic stimulation: Upregulation of SPARC in the myocardium of adult rats. J Mol Cell Cardiol 1998; 30(8):1505-14.

Franzosi MG, Santoro E, De Vita C, Geraci E, Lotto A, Maggioni AP, Mauri F, Rovelli F, Santoro L, Tavazzi L, Tognoni G, on behalf of GISSI Investigators.
Ten-year follow-up of the first megatrial testing thrombolytic therapy in patients with acute myocardial infarction: results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 study. The GISSI Investigators. Circulation 1998; 98: 2659-2665.

Santoro E, Nicolis E, Franzosi MG, Tognoni G.
Internet for clinical trials: past, present, and future. Control Clin Trials 1999 Apr;20(2):194-201

Villella M, Villella A, Barlera S, Franzosi MG, Maggioni AP, on behalf of the GISSI-2 Investigators.
Prognostic significance of double product and inadequate double product response to maximal symptom-limited exercise stress testing after myocardial infarction in 6296 patients treated with thrombolytic agents. Am Heart J 1999 Mar;137(3):443-52

Santoro E, Nicolis E, Franzosi MG.
Telecommunication technology for the management of large scale clinical trials: the GISSI experience. Comput Methods Programs Biomed 1999 Nov;60(3):215-23

In Press


Home Page Department  Home Page Institute

Department of Cardiovascular Research
"Mario Negri" Institute for Pharmacological Research

Via Eritrea, 62 - 20157 Milano - Italy
Tel. +39-0239014482 Fax. +39-0233200049


Scientific Info:DepCardio
Technical Info:Enrico Nicolis