Objective: To evaluate if and to what extent pharmacological treatments
aimed at different and probably complementary risk factors for atherosclerosis
and/or thrombosis improve the profile (in terms of survival, morbidity, quality
of health) of patients surviving beyond the hospital phase of acute myocardial
Study design: Open controlled clinical trial with central randomisation
of patients, following a 2x2 factorial design, to fish oil, vitamin E, both
or neither. Patients with high cholesterol levels (> 250 mg%) subsequently
randomised to receive pravastatin treatment 6 months after the event.
Population randomised: the study was started in October 1993 and
randomisation terminated in October 1995, after the inclusion of 11,324 patients.
A minimum follow-up period of 3 years is planned.
Results: expected in March 1999. <On-line results>
Protocollo dello studio
GISSI-Prevenzione. Studio di intervento preventivo sulle componenti
aterosclerotica e trombotica del rischio post-infarto. G Ital Cardiol 1993;